The fancy dan places solely offer binaries, offer match bonuses and have very enthusiastic customer sevices sales teams. It isn't so easy to withdraw money and often it isnt possible as customer withdrawals are not part of their business model. I feel this is a drawback.
.. and just to add another point.. the fancy dan places are mostly owned by companies that also operate online poker/casino sites. Regulation (Cysec) is just another feather in the cap that they use in their marketing but nothing beyond giving a false sense of security.
The theme being, 'house always wins'... but if someone/anyone is hell bent on crossing the bridge.. no sympathy for fools.